• If you are citizen of an European Union member nation, you may not use this service unless you are at least 16 years old.

  • Stop wasting time looking for files and revisions! Dokkio, a new product from the PBworks team, integrates and organizes your Drive, Dropbox, Box, Slack and Gmail files. Sign up for free.

View
 

fungemia case reports summary

Page history last edited by jens 7 years, 2 months ago

00:46

  • Fungemia Case reports of patients on Florastor

  • Lungarotti

    • 1mo preterm infant, revieving parenteral nutrition, CVC present

    • recovered with treatment

    • used to prevent SIBO

    • ref: Lungarotti MS, Mezzetti D, Radicioni M. Methaemoglobinaemia with concurrent blood isolation of Saccharomyces and Candida. Arch Dis Child Fetal Neonatal Ed 2003;88:F446.

  • Perapoch

    • 3mo w/ cardiomyopathy, on parenteral nutrition, CVC, used to treat diarrhea, unknown immuncompetence

    • fungemia resolved with treatment

    • ref: Perapoch J, Planes AM, Querol A, et al. Fungemia with Saccharomyces cerevisiae in two newborns, only one of whom had been treated with Ultra-Levura. Eur J Clin Microbiol Infect Dis 2000;19:468–70

  • Cesaro

    • 8mo leukemia, CVC, chemo, not immunocompetent

    • oral therapy, used to prevent AAD

    • ref: Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504–5.

  • Pletinex

    • 1yo, w/ pneumonia, enteritis, on parenteral nutrition, CVC, malnutrition, immunocompromised

    • 600mg/d oral, used to treat diarrhea

    • ref: Pletincx M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113–5.

  • Viggiano

    • 14yo burn pt, on enteral nutrition, CVC, unknown immuncompetence

    • 150mg/day per PEG used to prevent diarrhea

    • ref: Viggiano M, Badetti C, Bernini V, Garabedian M, Manelli JC. Fonge ́mie a` Saccharomyces boulardii chez un bruˆle ́ grave. [Saccharomyces boulardii fungemia in a patient with severe burns.] Ann Fr Anesth Reanim 1995;14:356–8

  • Burkhardt

    • 19yo Tetraparesis, entereal nutrition, on PPI and prokinetic

    • 150mg/d per PEG used to prevent diarrhea

    • ref: Burkhardt O, Ko ̈hnlein T, Pletz M, Welte T. Saccharomyces boulardii induced sepsis: successful therapy with voriconazole after treatment failure with fluconazole. Scand J Infect Dis 2005;37:69–72.

  • Zunic

    • 33 yo Colectomy, septic, enteral nutrition, CVC, H2 antagonist, unknown immuncompetence

    • 1500mg/day per NGT used to prevent AAD

    • Ref: Zunic P, Lacotte J, Pegoix M, et al. Fonge ́mie a` Saccharomyces bou- lardii. A propos d’un cas. [Saccharomyces boulardii fungemia. Apro- pos of a case.] Therapie 1991;46:498–9 (in French).

  • Lestin

    • 48yo Diabetic w/ foot necrosis, pneumonia, CVC, active C diff

    • used to treat CDAD, 150mg/day per NGT

    • ref: Lestin F, Pertschy A, Rimek D. Funga ̈mie nach oraler Gabe Saccha- romyces boulardii bei einem multimorbiden Patienten. [Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities.] Dtsch Med Wochenschr 2003;128:2531–3 (in German).

  • Fredenucci

    • 49 yo w/ pneumonia, on enteral nutrition, on antibiotics, unknown immuncompetence

    • used to treat enteral nutrition diarrhea

    • ref: Fredenucci I, Chomarat M, Boucaud C, Flandrois JP. Saccharomyces boulardii fungemia in a patient receiving Ultra-Levure therapy. Clin Infect Dis 1998;27:222–3.

  • hennequin

    • 2yo w/ cystic fibrosis, ileal atresia, on parenteral nutrition, CVC, unknown immuncompetence

    • 750mg/day to prevent diarrhea

    • ref: Hennequin C, Kauffmann-Lacroix C, Jobert A, et al. Possible role of catheters in Saccharomyces boulardii fungemia. Eur J Clin Microbiol Infect Dis 2000;19:16–20.

  • henniquin

    • 36 yo with HIV/aids, lymphoma, parenteral nutrition, CVC, on chemo, not immunocompetent

    • 150mg/day to treat diarrhea

    • recovered

  • Henniquin

    • 47 yo with esophageal cancer, on enteral nutrition, CVC, unknown immuncompetence

    • 2000mg/day used to treat AAD

  • henniquin

    • 78 yo with ‘pulmonary disease’, on enteral nutrition, CVC, unknown immuncompetence

    • 1500mg/day to prevent diarrhea

  • Lherm

    • 50 yo cardiac arrest, on enteral nutrition, CVC, ICU, immunocompetent

    • 1500mg/day to prevent diarrhea

    • death not attributable to fungemia

    • ref: Lherm T, Monet C, Nougiere B, et al. Seven cases of fungemia with S. boulardii in critically ill patients. Intensive Care Med 2002;28: 797–801.

  • Lherm

    • 51 yo F aortic surgery, cachexia, on enteral nutrition, CVC, ICU, not immuncompetent

    • 1000mg/day to prevent diarrhea

    • death (not attributable to fungemia)

  • Lherm

    • 71 yo F stroke patient, on enteral nutrition, CVC, ICU, not immunocompetent

    • 3000mg/day to prevent diarrhea

  • Lherm

    • 75 yo M respiratory failure patient on enteral nutrition, CVC, ICU, unknown immunocompetence

    • 2000mg/day to prevent diarrhea

  • Lherm

    • 77 yo M with peritonitis, on enteral nutrition, CVC, ICU, not immuncompetent

    • 3000mg/day to prevent diarrhea

  • Lherm

    • 82 yo F with respiratory failure, enteral nutrition, CVC, ICU, unknown immunocompetence

    • 1500mg/d to prevent diarrhea

  • Lolis

    • 56 yo with pneumonia, sepsis, on parenteral nutrition, CVC

    • 2000mg/day by NGT to treat diarrhea

    • ref: Lolis N, Veldekis D, Moraitou H, et al. Saccharomyces boulardii fungaemia in an intensive care unit patient treated with caspofungin. Crit Care 2008;12:414.

  • Henry

    • 65 yo with oropharyngeal cancer, on parenteral nutrition, CVC, mucositis

    • 6 capsules/day to treat diarrhea

    • ref: Henry S, D’Hondt L, Andre ́ M, Holemans X, Canon JL. Saccharo- myces cerevisiae fungemia in a head and neck cancer patient: a case report and review of the literature. Acta Clin Belg 2004;59:220–2.

  • Munoz

    • 65 yo s/p cardiac surgery on EN and PN, CVC, active c diff

    • per NGT to treat CDAD

    • ref: Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40: 1625–34. g/day per PEG to “prevent” CDAD?

  • Munoz

    • 74 yo s/p MV replacement, on EN and PN, CVC, active c diff

    • per ngt to treat CDAD

  • Munoz

    • 76 yo s/p MV replacement and cardiac arrest, on EN and PN, CVC, active c diff

    • per NGT to treat CDAD

  • Rijinders

    • 74 yo neurosurgery pt with subarachnoidal hematoma, ICU patient, CVC, colitis,

    • 600mg/day to treat EN diarrhea

    • immunocompetent

    • ref: Rijnders BJ, Van Wijngaerden E, Verwaest C, Peetermans WE. Sac- charomyces fungemia complicating Saccharomyces boulardii treatment in a non-immuno-compromised host. Intensive Care Med 2000;26:825.

  • Niault

    • 78 yo with pulmonary disease, on EN, CVC

    • 1500mg/day per NGT to treat diarrhea

    • ref: Niault M, Thomas F, Prost J, Ansari FH, Kalfon P. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.

  • Cherifi

    • 89 yo with C diff, anorexia nervosa, on EN, PVC

    • 300m

    • Cherifi S, Robberecht J, Miendje Y. Saccharomyces cerevisiae funge- mia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg 2004;59:223–4.

  • Bassetti

    • 51 yo F with CVC, intestinal disease, unknown immuncompetence

  • Neighbor cases

  • Gavazzi

    • 66 yo gastric adenocarcinoma, active chemo, high dose steroids, CVC, TPN

    • a patient in neighboring room was receiving S boulardii preparation for C diff diarrhea

    • Patient developed S Cerevisiae bacteremia

    • Patient died of metastatic cancer, fungemia may have contributed

    • ref: Graf C, Gavazzi G. Saccharomyces cerevisiae fungemia in an immu- nocompromised patient not treated with S. boulardii preparation. J Infect 2007;54:310–1.

  • Cassone Case 1

    • 34 yo M head and thoracic trauma patient, immunocompetent, in ICU, receiving enteral nutrition, CVC present, neighbor receiving S boulardii, developed S. Cerevisiae fungemia, resolved with tx.

  • Cassone Case 2

    • 48 yo M w/ cerebral aneurysm rupture, immunocompetent, in ICU, receiving enteral nutrition, CVC present, developed fever and S. Cerevisiae fungemia, resolved with tx.

  • Cassone Case 3:

    • 75 yo F w/ acute MI, immunocompetent, on enteral nutrition, ICU patient, CVC present, developed S. Cerevisiae fungemia. CVC tip + for S. Cerevisiae. Responded to tx.

    • Ref: Cassone M, Serra P, Mondello F, et al. Outbreak of Saccharomyces cerevisiae subtype boulardii fungemia in patients neighboring those treated with a probiotic preparation of the organism. J Clin Microbiol 2003;41:5340–3.

  • Perapoch

    • 1mo with intestinal disease, CVC, unknown immuncompetence

    • resolved with treatment

    • ref: Perapoch J, Planes AM, Querol A, et al. Fungemia with Saccharomyces cerevisiae in two newborns, only one of whom had been treated with Ultra-Levura. Eur J Clin Microbiol Infect Dis 2000;19:468–70

  • Lherm

    • 50 yo M with ARDS, gastric ulcer, CVC, ICU, immunocompetent

    • 1500mg/day to prevent diarrhea

    • catheter tip grew S boulardii.

    • Authors presume fungemia was from neighbor contamination

    • Resolved with treatment

    • ref: Lherm T, Monet C, Nougiere B, et al. Seven cases of fungemia with S. boulardii in critically ill patients. Intensive Care Med 2002;28: 797–801.

 

Comments (0)

You don't have permission to comment on this page.